about.

Siobhan is a photographer based in South Wales who specialises in Live Music, Landscape and Lifestyle photography.

She is also studying at the Centre for Neuropsychiatric Genetics and Genomics, Cardiff Univeristy, where she is researching predictors of treatment outcomes in schizophrenia. She is funded by a John Grace QC PhD Scholarship 2022 award by Mental Health Research UK, and we thank them for supporting this research.

photo.

aonach eagach
schiehallion
three sisters
oli sykes of bmth
james arthur
steve morse of deep purple
waterfall
dinefwr castle
Floating in the plunge pool at Sgwrd Gwladys
Model 1 & 2 wall clocks at Paulin Watches in Glasgow.
Liam Gallagher standing with tamborine
Milky Way rising over the ice tower at Dunraven Bay
Hayley Williams of Paramore
Waiting bottles ready to be filled with Merlyn Cream Liqueur at Penderyn Distillery.
Putting the final hand touches on a wrist watch, Paulin Watches in Glasgow.
nash point
Anthony Joshua at the Weigh In at Joshua vs Takam 2017.
pdj nantes.
marloes sands
falls of bruar
Sanding down a blank at Waterbourne Surfboards in Porthcawl.

science.

Skills

Computing: R (mostly), bash/CLI (partly), python (barely)


Statistics: regression, CFA/SEM, data vis, PGx, PGS, meta-analysis

Teaching

Lead: Pharmacogenomics of Schizophrenia, Polygenic Scores

Assisting: PCA, Genetic Correlations

Supervision: MSc Bioinformatics MET584 and Dissertation projects

Qualifications: Associate Fellow in Higher Education (AFHEA)


Funding

External: Mental Health Research UK, Guarantors of Brain, Genetics Society


Internal: DPMCN ECR Travel and Development Award, Future Leadership and Innovation for Pre- and Postdoctoral Excellent Researcher




Bibliography


  • Near, far, wherever you are: Phenotype-related variation in pharmacogenomic effect sizes across the psychiatric drug literature.

    Lock, S. K. , Kappel, D. B., Hutton, J., Simmonds, E., Legge, S. E., O’Donovan, M. C., & Pardiñas, A. F. (2025).

    doi: 10.3389/fphar.2025.1719761
  • Integrating Genome-wide and Epigenome-wide Associations for Antipsychotic Induced Extrapyramidal Side Effects

    Yao, K., Thygesen, J. H., Lock, S. K., Pardiñas, A. F., Pritchard, A. L., O’Donovan, M. C., ... & McQuillin, A. (2025)

    doi: 10.1007/s00213-025-06912-w
  • Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophrenia.

    Lock, S. K., Kappel, D. B., Owen, M. J., Walters, J. T., O'Donovan, M. C., Pardiñas, A. F., & Legge, S. E. (2025)

    doi: 10.1016/j.ebiom.2025.105745
  • Polygenic overlap with granulocyte counts identifies novel loci for clozapine metabolism and clozapine-induced agranulocytosis.

    Koch, E., Shadrin, A. A., Parker, N., Lock, S. K. , Smith, R. L., Frei, O., ... & Andreassen, O. A. (2025)

    doi: 10.1038/s41386-025-02054-x
  • Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count.

    Lock, S. K. , Legge, S. E., Kappel, D. B., Willcocks, I. R., Helthuis, M., Jansen, J., ... & Pardiñas, A. F. (2023)

    doi: 10.1038/s41537-023-00404-6


education.

  • PhD Project. 2022 - present
    New approaches in precision psychiatry: Exploring genomic markers and linked health records to predict symptom improvement and drug response in schizophrenia.
  • MSc Bioinformatics. 2021 - 2022
    Distinction.

    Dissertation project: Pharmacogenomic makeup and medication use in Schizophrenia. An Investigation of CYP Enzyme Metabolism Variables and Medication Phenotypes in the CardiffCOGS sample.

    Individual data project: Investigating the role of Abi3 in Microglia from recently published data by exploring differential gene expression and perfoming a pathway analysis.

    Group data project: A Cross-Cultural Exploration of Nutritional Impacts on Huntington’s Disease involving the development of a data dashboard in R Shiny and an examination of preliminary findings.
  • BSc Psychology. 2017 - 2021
    1st class.

    Dissertation project: Investigating the Impact of Cyfip1 Haploinsufficiency on Brain Structure and Plasticity After Training on a Biconditional Task

    Placement year: Using Diffusion Tensor Imaging to reconstruct subcortical white matter pathways.

    Summer internship: Does Moral Elevation buffer the Moral Licensing Effect?

contact.

  +44 7972 073610
  siobhan-lock@hotmail.co.uk
  locksk@cardiff.ac.uk
  South Wales, UK